Tetracycline-controlled expression of the Ryanodine receptor.
نویسندگان
چکیده
منابع مشابه
Differential expression of ryanodine receptor in the developing rat cochlea
Ryanodine receptors (RyRs) are one of the intracellular calcium channels involved in regulation of intracellular free calcium concentration ([Ca2+]i). The immunolocalization of RyRs was investigated in the developing rat cochlea at different postnatal days (PND). The change of [Ca2+]i in isolated outer hair cells (OHCs) was determined. Morphological results showed low expression of RyRs in the ...
متن کاملDifferential expression of ryanodine receptor in the developing rat
Ryanodine receptors (RyRs) are one of the intracellular calcium channels involved in regulation of intracellular free calcium concentration ([Ca]i). The immunolocalization of RyRs was investigated in the developing rat cochlea at different postnatal days (PND). The change of [Ca]i in isolated outer hair cells (OHCs) was determined. Morphological results showed low expression of RyRs in the Koll...
متن کاملRyanodine Receptor
1.1 Size and Evolution The ryanodine receptor (RyR) is a selective Ca release channel that is localized to the endoplasmic reticulum (ER) in both excitable and non-excitable cells. The RyR owes its name to the plant alkaloid and high affinity ligand ryanodine. The functional RyR exists as a tetramer composed of a single unit of approximately 565kDa. To date, it is the largest known ion channel....
متن کاملCan changes of ryanodine receptor expression affect cardiac contractility?
Yamamoto et al. [1] have shown in their recent article as follows. Initially the cell must be in a steady state with that the expression of cardiac ryanodine receptors is respect to Ca fluxes. This means that, on each beat, that decreased in dogs subjected to heart failure induced by amount of Ca which enters the cell via the calcium current rapid-pacing. This agrees with previous work showing ...
متن کاملRyanodine receptor type 3: why another ryanodine receptor isoform?
The family of ryanodine receptor (RyR) genes encodes three highly related Ca2+ release channels: RyR1, RyR2 and RyR3. Until about 10 years ago, RyRs were essentially known only for being the Ca2+ release channels of the sarcoplasmic reticulum of striated muscles, because of the high levels of expression of the RyR1 and RyR2 isoforms in skeletal and cardiac muscles, respectively. In contrast wit...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34575-5